“Kinetics of Strand Displacement and Hybridization on Wireframe DNA Nanostructures: Dissecting the Roles of Size, Morphology, and Rigidity”

Casey M. Platnich, Amani A. Hariri, Janane F. Rahbani, Jesse B. Gordon, Hanadi F. Sleiman, Gonzalo Cosa, ACS Nano. Dec 2018.

“Printing” DNA Strand Patterns on Small Molecules with Control of Valency, Directionality and Sequence

Tuan Trinh, Daniel Saliba, Chenyi Liao, Donatien de Rochambeau, Alexander L. Prinzen, Jianing Li, Hanadi F. Sleiman, Angew. Chem. Int. Ed. Oct 2018

Templated synthesis of spherical RNA nanoparticles with gene silencing activity

Michael D. DoreJohans J. FakhouryAurélie Lacroix and Hanadi F. Sleiman, Chem. Commun. 2018.

image file: c8cc06994h-s1.tif


Modular Strategy To Expand the Chemical Diversity of DNA and Sequence-Controlled Polymers

Donatien de RochambeauYuanye SunMaciej BarlogHassan S. Bazzi, and Hanadi F. Sleiman, J. Org. Chem.201883 (17), 9774–9786.

Abstract Image


DNA-Imprinted Polymer Nanoparticles with Monodispersity and Prescribed DNA-Strand Patterns

Tuan Trinh, Chenyi Liao, Violeta Toader, Maciej Barłóg, Hassan S. Bazzi, Jianing Li, Hanadi F. Sleiman, Nature Chem. 2018, 10, 184–192.


Mapping the energy landscapes of supramolecular assembly by thermal hysteresis

Robert W. Harkness V, Nicole Avakyan, Hanadi F. Sleiman & Anthony K. Mittermaier

Nature Communications, 2018, 9, Article number: 3152


DNA Nanostructures at the Interface with Biology

Katherine Bujold, Aurelie Lacroix, Hanadi Sleiman, Chem, 2018, 4, 495-521.


Cyanine-mediated DNA nanofiber growth with controlled dimensionality

Danny Bousmail, Pongphak Chidchob, Hanadi Sleiman, J. Am. Chem. Soc., 2018, 140, 9518–9530


Optimized DNA “nanosuitcases” for encapsulation and conditional release of siRNA

Katherine E. Bujold, Hassan H. Fakih and Hanadi F. Sleiman, Methods Mol. Biol., “RNA interference and cancer therapy”, Springer Nature, 2018, in press.


Recent Advances in DNA Nanotechnology

Pongphak Chidchob, Hanadi F. Sleiman, Curr. Opin. Chem. Biol., 2018, 46, 63-70.


Encapsulation of gold nanoparticles into DNA minimal nanocages for complex anisotropic functionalization and assembly

Xin Luo, H. F. Sleiman, Small, 2018, 14, 1702660.


DNA Nanotubes with Hydrophobic Environments: Toward New Platforms for Guest Encapsulation and Cellular Delivery

Janane Rahbani, Empar Vengut-Climent, Pongphak Chidchob, Yasser Gidi, Tuan Trinh, Gonzalo Cosa and Hanadi F. Sleiman, Adv. Healthcare Mater., 2018, 7, 1701049.


Single-stranded templates as railroad tracks for hierarchical assembly of DNA origami

Janane Rahbani, John Hsu, Pongphak Chidchob, Hanadi Sleiman, Nanoscale, 2018, 10, 13994-13999


DNA nanotechnology

Nadrian Seeman, Hanadi  Sleiman, Nature Reviews Materials 3, natrevmats201768

Efficient and Rapid Mechanochemical Assembly of Platinum (II) Squares for Guanine Quadruplex Targeting

A. Garci, K. J Castor, J. J Fakhoury, J.-L. Do, J. Di Trani, R. S Stein, A. K Mittermaier, T. Friscic*, H. F Sleiman*, J. Am. Chem. Soc. 2017, 139, 16913–16922.

Long-Range Ordering of Blunt-Ended DNA tiles on Supported Lipid Bilayers

N. Avakyan, J. Conway, H. F. Sleiman, J. Am. Chem. Soc. 2017, 139, pp 12027–12034.

Stoichiometry and dispersity of DNA nanostructures using photobleaching pair correlation analysis

A. A. Hariri, G. D. Hamblin, J. S. Hardwick, R. Godin, J.-F. Desjardins, P. W. Wiseman, H. F. Sleiman, G. Cosa, Bioconj. Chem. 2017, 28, 2340-2349.

Precision Spherical Nucleic Acids for Delivery of Anticancer Drugs

D. Bousmail, L. Amrein, J. J. Fakhoury, H. H. Fakih, J. C.C. Hsu, L. Panasci, H. F. Sleiman, Chem. Sci. 2017, 8, 6218-6229.

Development of DNA nanostructures for high affinity binding to human serum albumin

A. Lacroix, T. G. W. Edwardson, M. D. Dore, M. A. Hancock, H. F. Sleiman, J. Am. Chem. Soc. 2017, 139, 7355–7362

Supramolecular DNA Nanotechnology

J. Conway, H. Sleiman, Supramolecular Chemistry II, Elsevier, 2017

Cuvette‐Based Electrogenerated Chemiluminescence Detection System for the Assessment of Polymerizable Ruthenium Luminophores

A. S Danis, W. L Odette, S. C Perry, S. Canesi, H. F Sleiman, J. Mauzeroll, ChemElectroChem, 4, 1736–1743


Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

Katherine E. Bujold, John C. C. Hsu, and Hanadi F. Sleiman, J. Am. Chem. Soc., 2016, 138, 14030–14038, JACS Spotlight, “FOR A THERAPEUTIC TRIP, PACK A
NANOSUITCASE” (jacs%2e6b11489)

DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi, Hanadi F. Sleiman, Chem. Comm., 2016, 52, 10914-10917

Minimalist Approach to Complexity: Templating the Assembly of DNA Tile Structures with Sequentially Grown Input Strands

Kai Lin Lau, Hanadi Sleiman, ACS Nano, 2016, 10, 6542–6551

“DNA-Teflon” sequence-controlled polymers
Donatien de Rochambeau, Maciej Barłóg, Thomas Edwardson, Johans Fakhoury, Robin Stein, Hassan Bazzi and Hanadi Sleiman

Polymer Chem. 2016, 7, 4998-5003.

Synergy of Two Assembly Languages in DNA Nanostructures: Self-Assembly of Sequence-Defined Polymers on DNA Cages

P. Chidchob, T. W. Edwardson, C. J. Serpell, H. F. Sleiman,

J. Am. Chem. Soc. 2016, 138, 4416–4425.


Reprogramming the assembly of unmodified DNA with a small molecule

Nicole Avakyan, Andrea Greschner, Faisal Aldaye, Violeta Toader, Anne Petitjean, Hanadi Sleiman,

Nature Chemistry, 2016, 8, 368-376.

Press coverage: “From backyard pool chemical to nanomaterial

TOC figure

Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles
Thomas G. W. Edwardson, Kai Lin Lau, Danny Bousmail, Hanadi Sleiman
Nature Chemistry, 2016, 8,162–170

Press coverage: “A printing press for nanoparticles” McGill, Canadian Chemical News, other sources.



Dynamic DNA Nanotubes: Reversible Switching between Single and Double-Stranded Forms, and Effect of Base Deletions
Janane Rahbani, Amani Hariri, Gonzalo Cosa* and Hanadi Sleiman*
ACS Nano 2015, 9, pp 11898–11908.


Antisense precision polymer micelles require less poly(ethylenimine) for efficient gene knockdown
Johans Fakhoury, Tom Edwardson, Justin Conway, Tuan Trinh, Farhad Khan, Maciej Barlog, Hassan Bazzi, Hanadi  Sleiman
Nanoscale, 2015, 7, 20625-20634


Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders
Katherine J. Castor , Kimberly L. Metera , Ushula M. Tefashe , Christopher J. Serpell , Janine Mauzeroll *, and Hanadi F. Sleiman *
Inorg. Chem., 2015, 54 (14), pp 6958–6967


Sequential growth of long DNA strands with user-defined patterns for nanostructures and scaffolds
G. Hamblin, J. Rahbani, H. Sleiman,
Nature Commun., 2015, 6, Article number: 7065


Stepwise growth of surface-grafted DNA nanotubes visualized at the single molecule level
A. Hariri, G. D. Hamblin, H. F. Sleiman* and G. Cosa*
Nature Chem. 2015, 7, 295-300.

Screen Shot 2015-03-11 at 9.37.09 AM

Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes
Philippe Dauphin-Ducharme , Fiora Rosati , Andrea Greschner , A. Dowine De Bruijn , Danielle Salvatore , Violeta Toader , Kai Lin Lau , Janine Mauzeroll*, and Hanadi Sleiman*
Langmuir, 2015, 31 , 1850–1854

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Precision Polymers and 3D DNA Nanostructures: Emergent Assemblies from New Parameter Space
C. J. Serpell, T. G. W. Edwardson, P. Chidchob, K. M. M. Carneiro
J. Am. Chem. Soc. 2014, 136, 15767–15774, JACS Research Spotlight: “COMPLEX FUNCTIONALITY FROM DNA BOXES AND POLYMER SNAKES”



Sequence-Responsive Unzipping DNA Cubes with Tunable Cellular Uptake Profiles

K. E. Bujold, J. Fakhoury, T. G. W. Edwardson, K. M. M. Carneiro, J. N. Briard, A. G. Godin, L. Amrein, G. D. Hamblin, L. C. Panasci, P. W. Wiseman, H. Sleiman

Chemical Science, 2014, 5, 2449-2455.  Highlighted in Chemistry World (Royal Society for Chemistry), ‘DNA cube programmed for an exclusive reveal’, April 2014

TOC Chem Sci mod

Dynamic behavior of DNA cages anchored on spherically supported lipid bilayers.

Conway JW, Madwar C, Edwardson TG, McLaughlin CK, Fahkoury J, Lennox RB, Sleiman HF.

J Am Chem Soc. 2014 , 136 (37), pp 12987–12997


Controlled Growth of DNA Structures From Repeating Units Using the Vernier Mechanism.

Greschner AA, Bujold KE, Sleiman HF.

Biomacromolecules. 2014, 15, 3002-8


Mechatronic DNA devices driven by a G-quadruplex-binding platinum ligand.

Huang YC, Castor KJ, Sleiman HF, Sen D.

Bioorg Med Chem. 2014 , 22, 4376-83

 Sen paper

An efficient and modular route to sequence-defined polymers appended to DNA.

Edwardson TG, Carneiro KM, Serpell CJ, Sleiman HF.

Angew Chem Int Ed Engl. 2014, 53, 4567-71, “Very Important Paper”, Angewandte Front Cover


Development and characterization of gene silencing DNA cages.

Fakhoury JJ, McLaughlin CK, Edwardson TW, Conway JW, Sleiman HF.

Biomacromolecules. 2014, 15, pp 276–282

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A platinum(II) phenylphenanthroimidazole with an extended side-chain exhibits slow dissociation from a c-Kit G-quadruplex motif.

Castor KJ, Liu Z, Fakhoury J, Hancock MA, Mittermaier A, Moitessier N, Sleiman HF.

Chemistry, a European Journal, 2013 Dec 23;19(52):17836-45.


Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly.

Edwardson TG, Carneiro KM, McLaughlin CK, Serpell CJ, Sleiman HF.

Nat Chem. 2013 Oct;5(10):868-75.

 Edwardson 2013

Electrogenerated chemiluminescence of iridium-containing ROMP block copolymer and self-assembled micelles.

Tefashe UM, Metera KL, Sleiman HF, Mauzeroll J.

Langmuir. 2013 Oct 15; 29(41):12866-73.


Intercalators as molecular chaperones in DNA self-assembly.

Greschner AA, Bujold KE, Sleiman HF.

J Am Chem Soc. 2013 Jul 31;135(30):11283-8.

 Greschner 2013

Long-range assembly of DNA into nanofibers and highly ordered networks.

Carneiro KM, Avakyan N, Sleiman HF.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 May-Jun;5(3):266-85.

Simple design for DNA nanotubes from a minimal set of unmodified strands: rapid, room-temperature assembly and readily tunable structure.

Hamblin GD, Hariri AA, Carneiro KM, Lau KL, Cosa G, Sleiman HF.

ACS Nano. 2013 Apr 23;7(4):3022-8.

hamblin 2013


The role of organic linkers in directing DNA self-assembly and significantly stabilizing DNA duplexes.

Greschner AA, Toader V, Sleiman HF.

J Am Chem Soc. 2012 Sep 5;134(35):14382-9.


Three-dimensional organization of block copolymers on “DNA-minimal” scaffolds.

McLaughlin CK, Hamblin GD, Hänni KD, Conway JW, Nayak MK, Carneiro KM, Bazzi HS, Sleiman HF.

J Am Chem Soc. 2012 Mar 7;134(9):4280-6.

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Rolling circle amplification-templated DNA nanotubes show increased stability and cell penetration ability.

Hamblin GD, Carneiro KM, Fakhoury JF, Bujold KE, Sleiman HF.

J Am Chem Soc. 2012 Feb 15;134(6):2888-91.  Erratum in: J Am Chem Soc. 2012 Mar 21;134(11):5426.


Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.

Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF.

ChemMedChem. 2012 Jan 2;7(1):85-94.



Supramolecular DNA assembly.

McLaughlin CK, Hamblin GD, Sleiman HF.

Chem Soc Rev. 2011 Dec;40(12):5647-56.  Review.

A facile, modular and high yield method to assemble three-dimensional DNA structures.

McLaughlin CK, Hamblin GD, Aldaye FA, Yang H, Sleiman HF.

Chem Commun (Camb). 2011 Aug 21;47(31):8925-7. doi: 10.1039/c1cc11726b. Epub 2011 Jul 11.

Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions.

Yang H, Lo PK, McLaughlin CK, Hamblin GD, Aldaye FA, Sleiman HF.

Methods Mol Biol. 2011;749:33-47. doi: 10.1007/978-1-61779-142-0_3.

Chiral metal-DNA four-arm junctions and metalated nanotubular structures.

Yang H, Altvater F, de Bruijn AD, McLaughlin CK, Lo PK, Sleiman HF.

Angew Chem Int Ed Engl. 2011 May 9;50(20):4620-3. doi: 10.1002/anie.201007403. Epub 2011 Apr 26. No abstract available.


Loading and selective release of cargo in DNA nanotubes with longitudinal variation.

Lo PK, Karam P, Aldaye FA, McLaughlin CK, Hamblin GD, Cosa G, Sleiman HF.

Nat Chem. 2010 Apr;2(4):319-28. doi: 10.1038/nchem.575. Epub 2010 Mar 14.

Self-assembly of three-dimensional DNA nanostructures and potential biological applications.

Lo PK, Metera KL, Sleiman HF.

Curr Opin Chem Biol. 2010 Oct;14(5):597-607. doi: 10.1016/j.cbpa.2010.08.002. Epub 2010 Sep 24. Review.

Stable gold nanoparticle conjugation to internal DNA positions: facile generation of discrete gold nanoparticle-DNA assemblies.

Wen Y, McLaughlin CK, Lo PK, Yang H, Sleiman HF.

Bioconjug Chem. 2010 Aug 18;21(8):1413-6. doi: 10.1021/bc100160k.

Templated synthesis of DNA nanotubes with controlled, predetermined lengths.

Lo PK, Altvater F, Sleiman HF.

J Am Chem Soc. 2010 Aug 4;132(30):10212-4. doi: 10.1021/ja1017442.

Long-range assembly of DNA into nanofibers and highly ordered networks using a block copolymer approach.

Carneiro KM, Aldaye FA, Sleiman HF.

J Am Chem Soc. 2010 Jan 20;132(2):679-85. doi: 10.1021/ja907735m.


Templated ligand environments for the selective incorporation of different metals into DNA.

Yang H, Rys AZ, McLaughlin CK, Sleiman HF.

Angew Chem Int Ed Engl. 2009;48(52):9919-23. doi: 10.1002/anie.200904186. No abstract available.

Metal-nucleic acid cages.

Yang H, McLaughlin CK, Aldaye FA, Hamblin GD, Rys AZ, Rouiller I, Sleiman HF.

Nat Chem. 2009 Aug;1(5):390-6. doi: 10.1038/nchem.290. Epub 2009 Jul 24.

Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character.

Aldaye FA, Lo PK, Karam P, McLaughlin CK, Cosa G, Sleiman HF.

Nat Nanotechnol. 2009 Jun;4(6):349-52. doi: 10.1038/nnano.2009.72. Epub 2009 Apr 12.

Nucleobase-templated polymerization: copying the chain length and polydispersity of living polymers into conjugated polymers.

Lo PK, Sleiman HF.

J Am Chem Soc. 2009 Apr 1;131(12):4182-3. doi: 10.1021/ja809613n.

Evaluation of binding selectivities and affinities of platinum-based quadruplex interactive complexes by electrospray ionization mass spectrometry.

Pierce SE, Kieltyka R, Sleiman HF, Brodbelt JS.

Biopolymers. 2009 Apr;91(4):233-43. doi: 10.1002/bip.21130.


Assembling materials with DNA as the guide.

Aldaye FA, Palmer AL, Sleiman HF.

Science. 2008 Sep 26;321(5897):1795-9. doi: 10.1126/science.1154533. Review.

A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor.

Kieltyka R, Englebienne P, Fakhoury J, Autexier C, Moitessier N, Sleiman HF.

J Am Chem Soc. 2008 Aug 6;130(31):10040-1. doi: 10.1021/ja8014023. Epub 2008 Jul 11.

Templated synthesis of highly stable, electroactive, and dynamic metal-DNA branched junctions.

Yang H, Sleiman HF.

Angew Chem Int Ed Engl. 2008;47(13):2443-6. doi: 10.1002/anie.200703741.

Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders.

Kieltyka R, Fakhoury J, Moitessier N, Sleiman HF.

Chemistry. 2008;14(4):1145-54.



Modular access to structurally switchable 3D discrete DNA assemblies.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Nov 7;129(44):13376-7. Epub 2007 Oct 16. No abstract available.

Guest-mediated access to a single DNA nanostructure from a library of multiple assemblies.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Aug 22;129(33):10070-1. Epub 2007 Aug 1.

Dynamic DNA templates for discrete gold nanoparticle assemblies: control of geometry, modularity, write/erase and structural switching.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Apr 11;129(14):4130-1. Epub 2007 Mar 17. No abstract available.

Molecule-responsive block copolymer micelles.

Ishihara Y, Bazzi HS, Toader V, Godin F, Sleiman HF.

Chemistry. 2007;13(16):4560-70.


Sequential self-assembly of a DNA hexagon as a template for the organization of gold nanoparticles.

Aldaye FA, Sleiman HF.

Angew Chem Int Ed Engl. 2006 Mar 27;45(14):2204-9. No abstract available.

Hydrogen-bond self-assembly of DNA-analogues into hexameric rosettes.

Rakotondradany F, Palmer A, Toader V, Chen B, Whitehead MA, Sleiman HF.

Chem Commun (Camb). 2005 Nov 21;(43):5441-3. Epub 2005 Oct 4.




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