Sleiman Lab Publications


Control of the Assembly and Disassembly of Spherical Nucleic Acids is Critical for Enhanced Gene Silencing 

Jathavan Asohan, Hassan H Fakih, Trishalina Das, Hanadi F Sleiman 

ACS Nano. 2024, 18, 3996-4007. DOI:10.1002/ange.202217814

DNA-Mediated Peptide Assembly into Protein Mimics

Fangzhou Zhao, Martin Frandsen, Sabrina Capodaglio, Hanadi F Sleiman 

J. Am. Chem. Soc. 2024, 146, 3, 1946-1956. DOI:10.1002/ange.202217814

Automated Synthesis of Wireframe DNA Nanotubes

Patricia Islas, Casey M. Platnich, Yasser Gidi, Ryan Karimi, Lorianne Ginot, Gonzalo Cosa, Hanadi F Sleiman 

bioRxiv. 2024, 01, 18, 576297. DOI:10.1002/ange.202217814



Impact of the Core Chemistry of Self-Assembled Spherical Nucleic Acids on their In Vitro Fate

Sinan Faiad, Dr. Quentin Laurent, Dr. Alexander L. Prinzen, Jathavan Asohan, Dr. Daniel Saliba. Dr. Violeta Taoder, Prof. Hanadi F. Sleiman

Angew Chem. 2023, 135, 51. DOI:10.1002/ange. 202315768

Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy and low toxicity

Hassan H. Fakih, Qi Tang, Ashely Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman

Molecular Therapy-Nucleic Acids. 2023, 34, 102080. DOI:10.1016/j.omtn. 2023.102080

Minimalist Design of Wireframe DNA Nanotubes: Tunable Geometry, Size, Chirality, and Dynamics

Xin Luo, Daniel Saliba, Tianxiao Yang, Serena Gentile, Keita Mori, Patricia Islas, Trishalina Das, Neda Bagheri, Alessandro Porchetta, Alba Guarne, Gonzalo Cosa, Hanadi F. Sleiman

Angew. Chem. 2023, 62, 44. DOI:10.1002/anie.202309869

Supramolecular Nucleic Acid-Based Organosilica Nanoparticles Responsive to Physical and Biological Inputs 

Pierre Picchetti, Stefano Volpi, Maria Sancho-Albero, Marianna Rossetti, Michael D. Dore, Tuan Trinh, Frank Biedermann, Martin Neri, Alessandro Bertucci, Alessandro Porchetta, Roberto Corradini, Hanadi F Sleiman, Luisa De Cola

J. Am. Chem. Soc. 2023, 145, 42, 22903-22912. DOI:10.1021/jacs.3c04345

Responsive Nucliec Acid-Based Organosilica Nanoparticles

Pierre Picchetti, Stefano Volpu, Marianna Rossetti, Michael D Dore, Tuan Trinh, Frank Biedermann, Martina Neri, Alessandro Bertucci, Alessandro Porchetta, Roberto Corradini, Hanadi Sleiman, Luisa De Cola

J. Am. Chem. Soc. 2023, 145, 42, 22896-22902 DOI:10.1021/jacs.3c00393

Ultrabright DNA nanostructures for biosensing

Xighua Shi, Haidong Huang, Hassan H Fakih, Hanadi F Sleiman

US Patent Application

DNA-encoded functionalized apatamers

Hanadi Sleiman, Donatien Philippe, Marie Lacroix De Vimeur, De Rochame, Maureen McKeague, Serhii Hirka, Daniel Saliba, Shaun Ian Anderson

US Patent Application 

Two-Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence-Dependent DNA-Chromophore Interactions

Muhammad Ghufran Rafique, Jacob M Remington, Finley Clark, Haochen Bai, Violeta Toader, Dmytro F Perepichka, Jianing Li, Hanadi F Sleiman

Angew. Chem. 2023, 135-24. DOI:10.1002/ange.202217814

Sequence-Controlled Spherical Nucleic Acids: Gene Silencing, Encapsulation, and Cellular Uptake

Sepideh Kaviani, Hassan H Fakih, Jathavan Asohan, Adam Katolik, Masad J Damha, Hanadi F Sleiman

Nucleic Acid Ther. 2023, 2159-3337. DOI:10.1089/nat.2022.0062

A Single Monomer Difference can Impact the Nanostructure Output of Precision Oligo(phosphodiesters)

Donatien de Rochambeau, Maciej Barłóg, Felix Rizzuto, Quentin Laurent, Xin Luo, Kai Lin Lau, Hassan S Bazzi, Hanadi F Sleiman

Polym. Chem. 2023, 1759-9962. DOI: 10.1039/d3py00731f

Small Molecule-Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids

Christophe Lachance-Brais, Mostafa Rammal, Jathavan Asohan, Adam Katolik, Xin Luo, Daniel Saliba, Antranik Jonderian, Masad J. Damha, Matthew J. Harrington, Hanadi F. Sleiman

Adv. Sci.2023, 2205713. DOI: 10.1002/advs.202205713

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Stabilization of Functional DNA Structures with Mild Photochemical Methods

Tyler M. Brown, Hassan H. Fakih, Daniel Saliba, Jathavan Asohan, Hanadi F. Sleiman

J. Am. Chem. Soc.2023, 145, 4, 2142–2151 DOI: 10.1021/jacs.2c08808

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Programming rigidity into size-defined wireframe DNA nanotube

Daniel Saliba, Xin Luo, Felix Rizzuto, Hanadi Sleiman

Nanoscale 2023, 10.1039/D2NR06185F. DOI: 10.1039/D2NR06185F.



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DNA Sequence and Length Dictate the Assembly of Nucleic Acid Block Copolymers

Felix J. Rizzuto, Michael D. Dore, Muhammad Ghufran Rafique, Xin Luo, and Hanadi F. Sleiman

J. Am. Chem. Soc. 2022, 144, 27, 12272–12279 DOI: 10.1021/jacs.2c03506

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Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems

Christopher Hennecker , Christophe Lachance-Brais,  Hanadi F. Sleiman and Anthony Mittermaier

Science Adv., 2022, 8, 8455,DOI: 10.1126/sciadv.abm8455

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Asymmetric patterning drives the folding of a tripodal DNA nanotweezer

Daniel Saliba , Tuan Trinh, Christophe Lachance-Brais, Alexander L. Prinzen, Felix J. Rizzuto, Donatien de Rochambeau and Hanadi F. Sleiman

Chem. Sci., 2022, 13, 74-80, DOI: 10.1039/D1SC04793K



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Tuning DNA Supramolecular Polymers by the Addition of Small, Functionalized Nucleobase Mimics

Christophe Lachance-Brais, Christopher D. Hennecker, Asem Alenaizan, Xin Luo, Violeta Toader, Monica Taing, C. David Sherrill, Anthony K. Mittermaier, and Hanadi F. Sleiman*

J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c08972

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Thermosetting supramolecular polymerization of compartmentalized DNA fibers with stereo sequence and length control

Michael D. Dore, Tuan Trinh, Marlo Zorman, Donatien de Rochambeau, Casey M. Platnich, Pengfei Xu, Xin Luo, Jacob M. Remington, Violeta Toader, Gonzalo Cosa, Jianing Li, Hanadi F. Sleiman

Chem, 2021, DOI: 10.1016/j.chempr.2021.05.022

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DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery

Aurélie Lacroix and Hanadi F. Sleiman*

ACS Nano, 2021, DOI: 10.1021/acsnano.0c06136

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A dissipative pathway for the structural evolution of DNA fibres

Felix J. Rizzuto, Casey M. Platnich, Xin Luo, Yao Shen, Michael D. Dore, Christophe Lachance-Brais, Alba Guarné, Gonzalo Cosa & Hanadi F. Sleiman

Nat. Chem., 2021, DOI: 10.1038/s41557-021-00751-w

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Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)

Hassan H Fakih, Adam Katolik, Elise Malek-Adamian, Johans J Fakhoury, Sepideh Kaviani, Masad J Damha, Hanadi F Sleiman



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A poly(thymine)–melamine duplex for the assembly of DNA nanomaterials

Qian Li, Jiemin Zhao, Longfei Liu, Sagun Jonchhe, Felix J Rizzuto, Shankar Mandal, Huawei He, Sansen Wei, Hanadi F Sleiman, Hanbin Mao, Chengde Mao

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Molecular Printing with DNA Nanotechnology

Felix J. Rizzuto, Tuan Trinh, Hanadi F. Sleiman

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Single-molecule methods in structural DNA nanotechnology

Casey M. Platnich, Felix J. Rizzuto, Gonzalo Cosa, Hanadi F. Sleiman

Chem. Soc. Rev., 2020, DOI:10.1039/C9CS00776H

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Amplified Self‐Immolative Release of Small Molecules by Spatial Isolation of Reactive Groups on DNA‐Minimal Architectures

Alexander L Prinzen, Daniel Saliba, Christopher Hennecker, Tuan Trinh, Anthony Mittermaier, Hanadi F Sleiman

Angew. Chem. Int. Ed., 2020, DOI:10.1002/anie.202001123

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Selection of a metal ligand modified DNAzyme for detecting Ni2+

Wei Ren, Po-Jung Jimmy Huang, Donatien de Rochambeau, Woohyun J Moon, Jinyi Zhang, Mingsheng Lyu, Shujun Wang, Hanadi Sleiman, Juewen Liu

Biosen. Bioelectron., 2020, 112285.

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Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake

Aurélie Lacroix, Hassan H Fakih, Hanadi F Sleiman

J. Control. Release, 2020, DOI: 10.1016/j.jconrel.2020.04.020

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Target Self‐enhanced Selectivity in Metal‐specific DNAzymes

Po‐Jung Jimmy Huang, Donatien de Rochambeau, Hanadi F Sleiman, Juewen Liu

Angew. Chem. Int. Ed., 2020, 59, 3573.

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The assemble, grow and lift-off (AGLO) strategy to construct complex gold nanostructures with pre-designed morphologies

Xin Luo, Christophe Lachance-Brais, Amy Bantle, Hanadi F Sleiman

Chem. Sci., 2020, 19, 4911.

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Sequence-Defined DNA Amphiphiles for Drug Delivery: Synthesis and Self-Assembly

Michael D Dore, Hanadi F Sleiman

Nucleic Acid Detection and Structural Investigations, 2020.

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Transition Metal‐Functionalized DNA Double‐Crossover Tiles: Enhanced Stability and Chirality Transfer to Metal Centers

Alexander Rousina-Webb, Christophe Lachance-Brais, Felix J. Rizzuto, Mohammed Askari, Hanadi F. Sleiman

Angew. Chem. Int. Ed., 2020, DOI:10.1002/anie.201913956.



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Advancing Wireframe DNA Nanostructures Using Single-Molecule Fluorescence Microscopy Techniques

Casey M. Platnich, Amani A. Hariri, Hanadi F. Sleiman, Gonzalo Cosa

Acc. Chem. Res.2019, XXXX, XXX, XXX-XXX

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Bottom‐Up Characterization and Self‐Assembly of Electrogenerated Chemiluminescence Active Ruthenium Nanospheres

Andrew S. Danis, Kimberly L. Metera, Nicholas A. Payne, Hanadi F. Sleiman, Janine Mauzeroll

ChemElectroChem, 2019, 6, 3499-3506.

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Charting a course for chemistry

Hanadi F. Sleiman, et. al.

Nat. Chem., 2019, 11, 286-294.

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Spatial Presentation of Cholesterol Units on a DNA Cube as a Determinant of Membrane Protein-Mimicking Functions

Pongphak Chidchob, Daniel Offenbartl-Stiegert, Dillon McCarthy, Xin Luo, Jianing Li, Stefan Howorka, Hanadi F. Sleiman

J. Am. Chem. Soc.2019, 141, 1100-1108.

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Remote control of charge transport and chiral induction along a DNA-metallohelicate

Mohammad S. Askari, Christophe Lachance-Brais, Felix J. Rizzuto, Violeta Toader, Hanadi Sleiman

Nanoscale, 2019, 11, 11879-11884.

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Uptake and Fate of Fluorescently Labeled DNA Nanostructures in Cellular Environments: A Cautionary Tale

Aurélie Lacroix, Empar Vengut-Climent, Donatien de Rochambeau, Hanadi F. Sleiman

ACS Cent. Sci.2019,5, 882-891.

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Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics

Hassan H. Fakih, Johans J. Fakhoury, Danny Bousmail, Hanadi F. Sleiman

ACS Appl. Mater. Interfaces, 2019, 11, 13912-13920.

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“Printing” DNA Strand Patterns on Small Molecules with Control of Valency, Directionality, and Sequence

Tuan Trinh, Daniel Saliba, Chenyi Liao, Donatien de Rochambeau, Alexander Lee Prinzen, Jianing Li, Hanadi F. Sleiman

Angew. Chem. Int. Ed., 2019, 58, 3042–3047.

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Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” That Can Conditionally Release Their Cargo

Katherine E. Bujold, Hassan H. Fakih, Hanadi F. Sleiman

Methods in Mol. Biol., RNA Interference and Cancer Therapy, p. 69-81.



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Kinetics of Strand Displacement and Hybridization on Wireframe DNA Nanostructures: Dissecting the Roles of Size, Morphology, and Rigidity

Casey M. Platnich, Amani A. Hariri, Janane F. Rahbani, Jesse B. Gordon, Hanadi F. Sleiman, Gonzalo Cosa

ACS Nano, 2018, 12, 12836-12846.

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Templated synthesis of spherical RNA nanoparticles with gene silencing activity

Michael D. Dore, Johans J. Fakhoury, Aurélie Lacroix, Hanadi F. Sleiman

Chem. Commun., 2018, 54, 11296-11299.

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Modular Strategy To Expand the Chemical Diversity of DNA and Sequence-Controlled Polymers

Donatien de Rochambeau, Yuanye Sun, Maciej Barlog, Hassan S. Bazzi, Hanadi F. Sleiman

J. Org. Chem., 2018, 83, 9774-9786.

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DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns

Tuan Trinh, Chenyi Liao, Violeta Toader, Maciej Barłóg, Hassan S. Bazzi, Jianing Li, Hanadi F. Sleiman

Nat. Chem., 2018, 10, 184-192.

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Mapping the energy landscapes of supramolecular assembly by thermal hysteresis

Robert W. Harkness V, Nicole Avakyan, Hanadi F. Sleiman, Anthony K. Mittermaier

Nat. Commun., 2018, 9, Article number: 3152.

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DNA Nanostructures at the Interface with Biology

Katherine Bujold, Aurelie Lacroix, Hanadi Sleiman

Chem, 2018, 4, 495-521.

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Cyanine-mediated DNA nanofiber growth with controlled dimensionality

Danny Bousmail, Pongphak Chidchob, Hanadi Sleiman

J. Am. Chem. Soc., 2018, 1409518–9530.

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Recent Advances in DNA Nanotechnology

Pongphak Chidchob, Hanadi Sleiman

Curr. Opin. Chem. Biol., 2018, 46, 63-70.

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Encapsulation of gold nanoparticles into DNA minimal nanocages for complex anisotropic functionalization and assembly

Xin Luo, Hanadi F. Sleiman

Small, 2018, 14, 1702660.

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Single-stranded templates as railroad tracks for hierarchical assembly of DNA origami

Janane Rahbani, John Hsu, Pongphak Chidchob, Hanadi F. Sleiman

Nanoscale, 2018, 10, 13994-13999.



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DNA nanotechnology

Nadrian C. Seeman, Hanadi F. Sleiman

Nat. Rev. Mater., 2017, 3, Article number: 17068.

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Efficient and Rapid Mechanochemical Assembly of Platinum(II) Squares for Guanine Quadruplex Targeting

Amine Garci, Katherine J. Castor, Johans Fakhoury, Jean-Louis Do, Justin Di Trani, Pongphak Chidchob, Robin S. Stein, Anthony K. Mittermaier, Tomislav Friščić, Hanadi Sleiman

J. Am. Chem. Soc., 2017, 139, 16913-16922.

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Long-Range Ordering of Blunt-Ended DNA tiles on Supported Lipid Bilayers

Nicole Avakyan, Justin W. Conway, Hanadi F. Sleiman

J. Am. Chem. Soc. 2017, 139, 12027-12034.

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Stoichiometry and dispersity of DNA nanostructures using photobleaching pair correlation analysis

Amani A. Hariri, Graham D. Hamblin, Jack S. Hardwick, Robert Godin, Jean-Francois Desjardins, Paul W. Wiseman, Hanadi F. Sleiman, Gonzalo Cosa

Bioconjugate Chem., 2017, 28, 2340-2349.

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Precision Spherical Nucleic Acids for Delivery of Anticancer Drugs

Danny Bousmail, Lilian Amrein, Johans J. Fakhoury, Hassan H. Fakih, John C. C. Hsu, Lawrence Panasc, Hanadi F. Sleiman

Chem. Sci., 2017, 8, 6218-6229.

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Development of DNA nanostructures for high affinity binding to human serum albumin

Aurélie Lacroix, Thomas G. W. Edwardson, Mark A. Hancock, Michael D. Dore, Hanadi F. Sleiman

J. Am. Chem. Soc., 2017, 139, 7355-7362.

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Supramolecular DNA Nanotechnology

Justin Conway, Hanadi F. Sleiman

Supramolecular Chemistry II, Elsevier, 2017.

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Cuvette‐Based Electrogenerated Chemiluminescence Detection System for the Assessment of Polymerizable Ruthenium Luminophores

Andrew S. Danis, William L. Odette, Samuel C. Perry, Sylvain Canesi, Hanadi F. Sleiman, Janine Mauzeroll

ChemElectroChem, 2017, 4, 1736–1743.



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Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

Katherine E. Bujold, John C. C. Hsu, Hanadi F. Sleiman

J. Am. Chem. Soc., 2016, 138, 14030–14038.

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DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules

Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi, Hanadi F. Sleiman

Chem. Comm., 2016, 52, 10914-10917.

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Minimalist Approach to Complexity: Templating the Assembly of DNA Tile Structures with Sequentially Grown Input Strands

Kai Lin Lau, Hanadi Sleiman

ACS Nano, 2016, 10, 6542–6551.

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“DNA–Teflon” sequence-controlled polymers

Donatien de Rochambeau, Maciej Barłóg, Thomas Edwardson, Johans Fakhoury, Robin Stein, Hassan Bazzi, Hanadi Sleiman

Polymer Chem., 2016, 7, 4998-5003.

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Synergy of Two Assembly Languages in DNA Nanostructures: Self-Assembly of Sequence-Defined Polymers on DNA Cages

Pongphak Chidchob, Thomas G. W. Edwardson, Christopher J. Serpell, Hanadi F. Sleiman

J. Am. Chem. Soc. 2016, 138, 4416–4425.

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Reprogramming the assembly of unmodified DNA with a small molecule

Nicole Avakyan, Andrea Greschner, Faisal Aldaye, Violeta Toader, Anne Petitjean, Hanadi Sleiman

Nat. Chem., 2016, 8, 368-376.

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Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles

Thomas G. W. Edwardson, Kai Lin Lau, Danny Bousmail, Hanadi Sleiman

Nat. Chem., 2016, 8, 162–170.



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Dynamic DNA Nanotubes: Reversible Switching between Single and Double-Stranded Forms, and Effect of Base Deletions

Janane Rahbani, Amani Hariri, Gonzalo Cosa, Hanadi Sleiman

ACS Nano, 2015, 9, 11898–11908.

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Antisense precision polymer micelles require less poly(ethylenimine) for efficient gene knockdown

Johans Fakhoury, Tom Edwardson, Justin Conway, Tuan Trinh, Farhad Khan, Maciej Barlog, Hassan Bazzi, Hanadi Sleiman

Nanoscale, 2015, 7, 20625-20634.

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Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders

Katherine J. Castor, Kimberly L. Metera, Ushula M. Tefashe, Christopher J. Serpell, Janine Mauzeroll, Hanadi F. Sleiman

Inorg. Chem., 2015, 54, 6958–6967.

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Sequential growth of long DNA strands with user-defined patterns for nanostructures and scaffolds

Graham D. Hamblin, Janane F. Rahbani, Hanadi F. Sleiman

Nat. Commun., 2015, 6, Article number: 7065.

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Stepwise growth of surface-grafted DNA nanotubes visualized at the single molecule level

Amani A. Hariri, Graham D. Hamblin, Yasser Gidi, Hanadi F. Sleiman, Gonzalo Cosa

Nat. Chem., 2015, 7, 295-300.

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Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes

Philippe Dauphin-Ducharme, Fiora Rosati, Andrea Greschner, A. Dowine De Bruijn, Danielle Salvatore, Violeta Toader, Kai Lin Lau, Janine Mauzeroll, Hanadi Sleiman

Langmuir, 2015, 31, 1850–1854.



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Precision Polymers and 3D DNA Nanostructures: Emergent Assemblies from New Parameter Space

Christopher J. Serpell, Thomas G. W. Edwardson, Pongphak Chidchob, Karina M. M. Carneiro, Hanadi F. Sleiman

J. Am. Chem. Soc., 2014, 136, 15767–15774.

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Sequence-Responsive Unzipping DNA Cubes with Tunable Cellular Uptake Profiles

Katherine E. Bujold, Johans Fakhoury, Thomas G. W. Edwardson, Karina M. M. Carneiro, Joel Neves Briard, Antoine G. Godin, Lilian Amrein, Graham D. Hamblin, Lawrence C. Panasci, Paul W. Wiseman, Hanadi F. Sleiman

Chem. Sci., 2014, 5, 2449-2455.

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Dynamic behavior of DNA cages anchored on spherically supported lipid bilayers

J. W. Conway, C. Madwar, T. G. Edwardson, C. K. McLaughlin, J. Fahkoury, R. B. Lennox, H. F. Sleiman

J. Am. Chem. Soc., 2014, 136, 12987-12997.

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Controlled Growth of DNA Structures From Repeating Units Using the Vernier Mechanism

Andrea A. Greschner, Katherine. E. Bujold, Hanadi F. Sleiman

Biomacromolecules. 2014, 15, 3002-3008.

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Mechatronic DNA devices driven by a G-quadruplex-binding platinum ligand

Yu Chuan Huang, Katherine J. Castor, Hanadi F. Sleiman, Dipankar Sena

Bioorg Med Chem., 2014, 22, 4376-4383.

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An efficient and modular route to sequence-defined polymers appended to DNA

Thomas G. W. Edwardson, Karina M. M. Carneiro, Christopher J. Serpell, Hanadi F. Sleiman

Angew. Chem. Int. Ed., 2014, 53, 4567-4571.

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Development and characterization of gene silencing DNA cages

Johans J. Fakhoury, Christopher K. McLaughlin, Thomas W. Edwardson, Justin W. Conway, Hanadi F. Sleiman

Biomacromolecules, 2014, 15, 276-282.

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Gold nanoparticle 3D-DNA building blocks: high purity preparation and use for modular access to nanoparticle assemblies.

Kai Lin Lau, Graham D. Hamblin, Hanadi F. Sleiman

Small, 2014, 10, 660-666.


A platinum(II) phenylphenanthroimidazole with an extended side-chain exhibits slow dissociation from a c-Kit G-quadruplex motif.

Castor KJ, Liu Z, Fakhoury J, Hancock MA, Mittermaier A, Moitessier N, Sleiman HF.

Chem. Eur. J., 2013 Dec 23;19(52):17836-45.

Site-specific positioning of dendritic alkyl chains on DNA cages enables their geometry-dependent self-assembly.

Edwardson TG, Carneiro KM, McLaughlin CK, Serpell CJ, Sleiman HF.

Nat. Chem. 2013 Oct;5(10):868-75.

Electrogenerated chemiluminescence of iridium-containing ROMP block copolymer and self-assembled micelles.

Tefashe UM, Metera KL, Sleiman HF, Mauzeroll J.

Langmuir, 2013 Oct 15; 29(41):12866-73.

Intercalators as molecular chaperones in DNA self-assembly.

Greschner AA, Bujold KE, Sleiman HF.

J. Am. Chem. Soc. 2013 Jul 31;135(30):11283-8.

Long-range assembly of DNA into nanofibers and highly ordered networks.

Carneiro KM, Avakyan N, Sleiman HF.

Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2013 May-Jun;5(3):266-85.

Simple design for DNA nanotubes from a minimal set of unmodified strands: rapid, room-temperature assembly and readily tunable structure.

Hamblin GD, Hariri AA, Carneiro KM, Lau KL, Cosa G, Sleiman HF.

ACS Nano. 2013 Apr 23;7(4):3022-8.


The role of organic linkers in directing DNA self-assembly and significantly stabilizing DNA duplexes.

Greschner AA, Toader V, Sleiman HF.

J. Am. Chem. Soc. 2012 Sep 5;134(35):14382-9.


Three-dimensional organization of block copolymers on “DNA-minimal” scaffolds.

McLaughlin CK, Hamblin GD, Hänni KD, Conway JW, Nayak MK, Carneiro KM, Bazzi HS, Sleiman HF.

J. Am. Chem. Soc. 2012 Mar 7;134(9):4280-6.


Rolling circle amplification-templated DNA nanotubes show increased stability and cell penetration ability.

Hamblin GD, Carneiro KM, Fakhoury JF, Bujold KE, Sleiman HF.

J. Am. Chem. Soc. 2012 Feb 15;134(6):2888-91.  Erratum in: J Am Chem Soc. 2012 Mar 21;134(11):5426.


Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.

Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF.

ChemMedChem. 2012 Jan 2;7(1):85-94.


Supramolecular DNA assembly.

McLaughlin CK, Hamblin GD, Sleiman HF.

Chem. Soc. Rev. 2011 Dec;40(12):5647-56.  Review.


A facile, modular and high yield method to assemble three-dimensional DNA structures.

McLaughlin CK, Hamblin GD, Aldaye FA, Yang H, Sleiman HF.

Chem. Commun. (Camb). 2011 Aug 21;47(31):8925-7. doi: 10.1039/c1cc11726b. Epub 2011 Jul 11.


Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions.

Yang H, Lo PK, McLaughlin CK, Hamblin GD, Aldaye FA, Sleiman HF.

Methods Mol. Biol. 2011;749:33-47. doi: 10.1007/978-1-61779-142-0_3.


Chiral metal-DNA four-arm junctions and metalated nanotubular structures.

Yang H, Altvater F, de Bruijn AD, McLaughlin CK, Lo PK, Sleiman HF.

Angew. Chem. Int. Ed. Engl. 2011 May 9;50(20):4620-3. doi: 10.1002/anie.201007403. Epub 2011 Apr 26. No abstract available.


Loading and selective release of cargo in DNA nanotubes with longitudinal variation.

Lo PK, Karam P, Aldaye FA, McLaughlin CK, Hamblin GD, Cosa G, Sleiman HF.

Nat. Chem. 2010 Apr;2(4):319-28. doi: 10.1038/nchem.575. Epub 2010 Mar 14.


Self-assembly of three-dimensional DNA nanostructures and potential biological applications.

Lo PK, Metera KL, Sleiman HF.

Curr. Opin. Chem. Biol. 2010 Oct;14(5):597-607. doi: 10.1016/j.cbpa.2010.08.002. Epub 2010 Sep 24. Review.


Stable gold nanoparticle conjugation to internal DNA positions: facile generation of discrete gold nanoparticle-DNA assemblies.

Wen Y, McLaughlin CK, Lo PK, Yang H, Sleiman HF.

Bioconjug. Chem. 2010 Aug 18;21(8):1413-6. doi: 10.1021/bc100160k.


Templated synthesis of DNA nanotubes with controlled, predetermined lengths.

Lo PK, Altvater F, Sleiman HF.

J. Am. Chem. Soc. 2010 Aug 4;132(30):10212-4. doi: 10.1021/ja1017442.


Long-range assembly of DNA into nanofibers and highly ordered networks using a block copolymer approach.

Carneiro KM, Aldaye FA, Sleiman HF.

J. Am. Chem. Soc. 2010 Jan 20;132(2):679-85. doi: 10.1021/ja907735m.



Templated ligand environments for the selective incorporation of different metals into DNA.

Yang H, Rys AZ, McLaughlin CK, Sleiman HF.

Angew Chem Int Ed Engl. 2009;48(52):9919-23. doi: 10.1002/anie.200904186. No abstract available.


Metal-nucleic acid cages.

Yang H, McLaughlin CK, Aldaye FA, Hamblin GD, Rys AZ, Rouiller I, Sleiman HF.

Nat Chem. 2009 Aug;1(5):390-6. doi: 10.1038/nchem.290. Epub 2009 Jul 24.


Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character.

Aldaye FA, Lo PK, Karam P, McLaughlin CK, Cosa G, Sleiman HF.

Nat Nanotechnol. 2009 Jun;4(6):349-52. doi: 10.1038/nnano.2009.72. Epub 2009 Apr 12.


Nucleobase-templated polymerization: copying the chain length and polydispersity of living polymers into conjugated polymers.

Lo PK, Sleiman HF.

J Am Chem Soc. 2009 Apr 1;131(12):4182-3. doi: 10.1021/ja809613n.


Evaluation of binding selectivities and affinities of platinum-based quadruplex interactive complexes by electrospray ionization mass spectrometry.

Pierce SE, Kieltyka R, Sleiman HF, Brodbelt JS.

Biopolymers. 2009 Apr;91(4):233-43. doi: 10.1002/bip.21130.


Assembling materials with DNA as the guide.

Aldaye FA, Palmer AL, Sleiman HF.

Science. 2008 Sep 26;321(5897):1795-9. doi: 10.1126/science.1154533. Review.


A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor.

Kieltyka R, Englebienne P, Fakhoury J, Autexier C, Moitessier N, Sleiman HF.

J Am Chem Soc. 2008 Aug 6;130(31):10040-1. doi: 10.1021/ja8014023. Epub 2008 Jul 11.


Templated synthesis of highly stable, electroactive, and dynamic metal-DNA branched junctions.

Yang H, Sleiman HF.

Angew Chem Int Ed Engl. 2008;47(13):2443-6. doi: 10.1002/anie.200703741.


Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders.

Kieltyka R, Fakhoury J, Moitessier N, Sleiman HF.

Chemistry. 2008;14(4):1145-54.


Modular access to structurally switchable 3D discrete DNA assemblies.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Nov 7;129(44):13376-7. Epub 2007 Oct 16. No abstract available.


Guest-mediated access to a single DNA nanostructure from a library of multiple assemblies.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Aug 22;129(33):10070-1. Epub 2007 Aug 1.


Dynamic DNA templates for discrete gold nanoparticle assemblies: control of geometry, modularity, write/erase and structural switching.

Aldaye FA, Sleiman HF.

J Am Chem Soc. 2007 Apr 11;129(14):4130-1. Epub 2007 Mar 17. No abstract available.


Molecule-responsive block copolymer micelles.

Ishihara Y, Bazzi HS, Toader V, Godin F, Sleiman HF.

Chemistry. 2007;13(16):4560-70.


Sequential self-assembly of a DNA hexagon as a template for the organization of gold nanoparticles.

Aldaye FA, Sleiman HF.

Angew Chem Int Ed Engl. 2006 Mar 27;45(14):2204-9. No abstract available.


Hydrogen-bond self-assembly of DNA-analogues into hexameric rosettes.

Rakotondradany F, Palmer A, Toader V, Chen B, Whitehead MA, Sleiman HF.

Chem Commun (Camb). 2005 Nov 21;(43):5441-3. Epub 2005 Oct 4.

Self-assembly of cyclic metal-DNA nanostructures using ruthenium tris(bipyridine)-branched oligonucleotides.

Mitra D, Di Cesare N, Sleiman HF.

Angew Chem Int Ed Engl. 2004 Nov 5;43(43):5804-8.


Ruthenium(II) dipyridoquinoxaline-norbornene: synthesis, properties, crystal structure, and use as a ROMP monomer.

Rezvani A, Bazzi HS, Chen B, Rakotondradany F, Sleiman HF.

Inorg Chem. 2004 Aug 9;43(16):5112-9.


Photoresponsive supramolecular systems: self-assembly of azodibenzoic acid linear tapes and cyclic tetramers.

Rakotondradany F, Whitehead MA, Lebuis AM, Sleiman HF.

Chemistry. 2003 Oct 6;9(19):4771-80.