Sleiman Lab Publications
2023

Small Molecule-Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids
Christophe Lachance-Brais, Mostafa Rammal, Jathavan Asohan, Adam Katolik, Xin Luo, Daniel Saliba, Antranik Jonderian, Masad J. Damha, Matthew J. Harrington, Hanadi F. Sleiman
Adv. Sci. 2023, 2205713. DOI: 10.1002/advs.202205713

Stabilization of Functional DNA Structures with Mild Photochemical Methods
Tyler M. Brown, Hassan H. Fakih, Daniel Saliba, Jathavan Asohan, Hanadi F. Sleiman
J. Am. Chem. Soc. 2023, 145, 4, 2142–2151 DOI: 10.1021/jacs.2c08808
Programming rigidity into size-defined wireframe DNA nanotube
Daniel Saliba, Xin Luo, Felix Rizzuto, Hanadi Sleiman
Nanoscale 2023, 10.1039/D2NR06185F. DOI: 10.1039/D2NR06185F.
2022
DNA Sequence and Length Dictate the Assembly of Nucleic Acid Block Copolymers
Felix J. Rizzuto, Michael D. Dore, Muhammad Ghufran Rafique, Xin Luo, and Hanadi F. Sleiman
J. Am. Chem. Soc. 2022, 144, 27, 12272–12279 DOI: 10.1021/jacs.2c03506
Using transient equilibria (TREQ) to measure the thermodynamics of slowly assembling supramolecular systems
Christopher Hennecker , Christophe Lachance-Brais, Hanadi F. Sleiman and Anthony Mittermaier
Science Adv., 2022, 8, 8455, DOI: 10.1126/sciadv.abm8455
Asymmetric patterning drives the folding of a tripodal DNA nanotweezer
Daniel Saliba , Tuan Trinh, Christophe Lachance-Brais, Alexander L. Prinzen, Felix J. Rizzuto, Donatien de Rochambeau and Hanadi F. Sleiman
2021
Tuning DNA Supramolecular Polymers by the Addition of Small, Functionalized Nucleobase Mimics
Christophe Lachance-Brais, Christopher D. Hennecker, Asem Alenaizan, Xin Luo, Violeta Toader, Monica Taing, C. David Sherrill, Anthony K. Mittermaier, and Hanadi F. Sleiman*
Thermosetting supramolecular polymerization of compartmentalized DNA fibers with stereo sequence and length control
Michael D. Dore, Tuan Trinh, Marlo Zorman, Donatien de Rochambeau, Casey M. Platnich, Pengfei Xu, Xin Luo, Jacob M. Remington, Violeta Toader, Gonzalo Cosa, Jianing Li, Hanadi F. Sleiman
DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery
Aurélie Lacroix and Hanadi F. Sleiman*

A dissipative pathway for the structural evolution of DNA fibres
Felix J. Rizzuto, Casey M. Platnich, Xin Luo, Yao Shen, Michael D. Dore, Christophe Lachance-Brais, Alba Guarné, Gonzalo Cosa & Hanadi F. Sleiman
Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)
Hassan H Fakih, Adam Katolik, Elise Malek-Adamian, Johans J Fakhoury, Sepideh Kaviani, Masad J Damha, Hanadi F Sleiman
2020
A poly(thymine)–melamine duplex for the assembly of DNA nanomaterials
Qian Li, Jiemin Zhao, Longfei Liu, Sagun Jonchhe, Felix J Rizzuto, Shankar Mandal, Huawei He, Sansen Wei, Hanadi F Sleiman, Hanbin Mao, Chengde Mao
Molecular Printing with DNA Nanotechnology
Felix J. Rizzuto, Tuan Trinh, Hanadi F. Sleiman

Single-molecule methods in structural DNA nanotechnology
Casey M. Platnich, Felix J. Rizzuto, Gonzalo Cosa, Hanadi F. Sleiman
Amplified Self‐Immolative Release of Small Molecules by Spatial Isolation of Reactive Groups on DNA‐Minimal Architectures
Alexander L Prinzen, Daniel Saliba, Christopher Hennecker, Tuan Trinh, Anthony Mittermaier, Hanadi F Sleiman

Selection of a metal ligand modified DNAzyme for detecting Ni2+
Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake
J. Control. Release, 2020, DOI: 10.1016/j.jconrel.2020.04.020

Target Self‐enhanced Selectivity in Metal‐specific DNAzymes

The assemble, grow and lift-off (AGLO) strategy to construct complex gold nanostructures with pre-designed morphologies
Xin Luo, Christophe Lachance-Brais, Amy Bantle, Hanadi F Sleiman
Sequence-Defined DNA Amphiphiles for Drug Delivery: Synthesis and Self-Assembly
Michael D Dore, Hanadi F Sleiman
Transition Metal‐Functionalized DNA Double‐Crossover Tiles: Enhanced Stability and Chirality Transfer to Metal Centers
Alexander Rousina-Webb, Christophe Lachance-Brais, Felix J. Rizzuto, Mohammed Askari, Hanadi F. Sleiman
2019
Advancing Wireframe DNA Nanostructures Using Single-Molecule Fluorescence Microscopy Techniques
Casey M. Platnich, Amani A. Hariri, Hanadi F. Sleiman, Gonzalo Cosa
Bottom‐Up Characterization and Self‐Assembly of Electrogenerated Chemiluminescence Active Ruthenium Nanospheres
Andrew S. Danis, Kimberly L. Metera, Nicholas A. Payne, Hanadi F. Sleiman, Janine Mauzeroll
Spatial Presentation of Cholesterol Units on a DNA Cube as a Determinant of Membrane Protein-Mimicking Functions
Pongphak Chidchob, Daniel Offenbartl-Stiegert, Dillon McCarthy, Xin Luo, Jianing Li, Stefan Howorka, Hanadi F. Sleiman
Remote control of charge transport and chiral induction along a DNA-metallohelicate
Mohammad S. Askari, Christophe Lachance-Brais, Felix J. Rizzuto, Violeta Toader, Hanadi Sleiman
Uptake and Fate of Fluorescently Labeled DNA Nanostructures in Cellular Environments: A Cautionary Tale
Aurélie Lacroix, Empar Vengut-Climent, Donatien de Rochambeau, Hanadi F. Sleiman
Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics
Hassan H. Fakih, Johans J. Fakhoury, Danny Bousmail, Hanadi F. Sleiman
“Printing” DNA Strand Patterns on Small Molecules with Control of Valency, Directionality, and Sequence
Tuan Trinh, Daniel Saliba, Chenyi Liao, Donatien de Rochambeau, Alexander Lee Prinzen, Jianing Li, Hanadi F. Sleiman
Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” That Can Conditionally Release Their Cargo
Katherine E. Bujold, Hassan H. Fakih, Hanadi F. Sleiman
Methods in Mol. Biol., RNA Interference and Cancer Therapy, p. 69-81.
2018
Kinetics of Strand Displacement and Hybridization on Wireframe DNA Nanostructures: Dissecting the Roles of Size, Morphology, and Rigidity
Casey M. Platnich, Amani A. Hariri, Janane F. Rahbani, Jesse B. Gordon, Hanadi F. Sleiman, Gonzalo Cosa
Templated synthesis of spherical RNA nanoparticles with gene silencing activity
Michael D. Dore, Johans J. Fakhoury, Aurélie Lacroix, Hanadi F. Sleiman
Modular Strategy To Expand the Chemical Diversity of DNA and Sequence-Controlled Polymers
Donatien de Rochambeau, Yuanye Sun, Maciej Barlog, Hassan S. Bazzi, Hanadi F. Sleiman
DNA-imprinted polymer nanoparticles with monodispersity and prescribed DNA-strand patterns
Tuan Trinh, Chenyi Liao, Violeta Toader, Maciej Barłóg, Hassan S. Bazzi, Jianing Li, Hanadi F. Sleiman
Mapping the energy landscapes of supramolecular assembly by thermal hysteresis
Robert W. Harkness V, Nicole Avakyan, Hanadi F. Sleiman, Anthony K. Mittermaier
DNA Nanostructures at the Interface with Biology
Katherine Bujold, Aurelie Lacroix, Hanadi Sleiman
Cyanine-mediated DNA nanofiber growth with controlled dimensionality
Danny Bousmail, Pongphak Chidchob, Hanadi Sleiman
Recent Advances in DNA Nanotechnology
Pongphak Chidchob, Hanadi Sleiman
Encapsulation of gold nanoparticles into DNA minimal nanocages for complex anisotropic functionalization and assembly
Xin Luo, Hanadi F. Sleiman
Single-stranded templates as railroad tracks for hierarchical assembly of DNA origami
Janane Rahbani, John Hsu, Pongphak Chidchob, Hanadi F. Sleiman
2017
DNA nanotechnology
Nadrian C. Seeman, Hanadi F. Sleiman
Efficient and Rapid Mechanochemical Assembly of Platinum(II) Squares for Guanine Quadruplex Targeting
Amine Garci, Katherine J. Castor, Johans Fakhoury, Jean-Louis Do, Justin Di Trani, Pongphak Chidchob, Robin S. Stein, Anthony K. Mittermaier, Tomislav Friščić, Hanadi Sleiman
Long-Range Ordering of Blunt-Ended DNA tiles on Supported Lipid Bilayers
Nicole Avakyan, Justin W. Conway, Hanadi F. Sleiman
Stoichiometry and dispersity of DNA nanostructures using photobleaching pair correlation analysis
Amani A. Hariri, Graham D. Hamblin, Jack S. Hardwick, Robert Godin, Jean-Francois Desjardins, Paul W. Wiseman, Hanadi F. Sleiman, Gonzalo Cosa
Precision Spherical Nucleic Acids for Delivery of Anticancer Drugs
Danny Bousmail, Lilian Amrein, Johans J. Fakhoury, Hassan H. Fakih, John C. C. Hsu, Lawrence Panasc, Hanadi F. Sleiman
Development of DNA nanostructures for high affinity binding to human serum albumin
Aurélie Lacroix, Thomas G. W. Edwardson, Mark A. Hancock, Michael D. Dore, Hanadi F. Sleiman
Supramolecular DNA Nanotechnology
Justin Conway, Hanadi F. Sleiman
Cuvette‐Based Electrogenerated Chemiluminescence Detection System for the Assessment of Polymerizable Ruthenium Luminophores
Andrew S. Danis, William L. Odette, Samuel C. Perry, Sylvain Canesi, Hanadi F. Sleiman, Janine Mauzeroll
2016
Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA
Katherine E. Bujold, John C. C. Hsu, Hanadi F. Sleiman
DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules
Tuan Trinh, Pongphak Chidchob, Hassan S. Bazzi, Hanadi F. Sleiman
Minimalist Approach to Complexity: Templating the Assembly of DNA Tile Structures with Sequentially Grown Input Strands
Kai Lin Lau, Hanadi Sleiman
“DNA–Teflon” sequence-controlled polymers
Donatien de Rochambeau, Maciej Barłóg, Thomas Edwardson, Johans Fakhoury, Robin Stein, Hassan Bazzi, Hanadi Sleiman
Synergy of Two Assembly Languages in DNA Nanostructures: Self-Assembly of Sequence-Defined Polymers on DNA Cages
Pongphak Chidchob, Thomas G. W. Edwardson, Christopher J. Serpell, Hanadi F. Sleiman
Reprogramming the assembly of unmodified DNA with a small molecule
Nicole Avakyan, Andrea Greschner, Faisal Aldaye, Violeta Toader, Anne Petitjean, Hanadi Sleiman
Transfer of molecular recognition information from DNA nanostructures to gold nanoparticles
Thomas G. W. Edwardson, Kai Lin Lau, Danny Bousmail, Hanadi Sleiman
2015
Dynamic DNA Nanotubes: Reversible Switching between Single and Double-Stranded Forms, and Effect of Base Deletions
Janane Rahbani, Amani Hariri, Gonzalo Cosa, Hanadi Sleiman
Antisense precision polymer micelles require less poly(ethylenimine) for efficient gene knockdown
Johans Fakhoury, Tom Edwardson, Justin Conway, Tuan Trinh, Farhad Khan, Maciej Barlog, Hassan Bazzi, Hanadi Sleiman
Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders
Katherine J. Castor, Kimberly L. Metera, Ushula M. Tefashe, Christopher J. Serpell, Janine Mauzeroll, Hanadi F. Sleiman
Sequential growth of long DNA strands with user-defined patterns for nanostructures and scaffolds
Graham D. Hamblin, Janane F. Rahbani, Hanadi F. Sleiman
Stepwise growth of surface-grafted DNA nanotubes visualized at the single molecule level
Amani A. Hariri, Graham D. Hamblin, Yasser Gidi, Hanadi F. Sleiman, Gonzalo Cosa
Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes
Philippe Dauphin-Ducharme, Fiora Rosati, Andrea Greschner, A. Dowine De Bruijn, Danielle Salvatore, Violeta Toader, Kai Lin Lau, Janine Mauzeroll, Hanadi Sleiman
2014
Precision Polymers and 3D DNA Nanostructures: Emergent Assemblies from New Parameter Space
Christopher J. Serpell, Thomas G. W. Edwardson, Pongphak Chidchob, Karina M. M. Carneiro, Hanadi F. Sleiman
Sequence-Responsive Unzipping DNA Cubes with Tunable Cellular Uptake Profiles
Katherine E. Bujold, Johans Fakhoury, Thomas G. W. Edwardson, Karina M. M. Carneiro, Joel Neves Briard, Antoine G. Godin, Lilian Amrein, Graham D. Hamblin, Lawrence C. Panasci, Paul W. Wiseman, Hanadi F. Sleiman
Dynamic behavior of DNA cages anchored on spherically supported lipid bilayers
J. W. Conway, C. Madwar, T. G. Edwardson, C. K. McLaughlin, J. Fahkoury, R. B. Lennox, H. F. Sleiman
Controlled Growth of DNA Structures From Repeating Units Using the Vernier Mechanism
Andrea A. Greschner, Katherine. E. Bujold, Hanadi F. Sleiman
Mechatronic DNA devices driven by a G-quadruplex-binding platinum ligand
Yu Chuan Huang, Katherine J. Castor, Hanadi F. Sleiman, Dipankar Sena
An efficient and modular route to sequence-defined polymers appended to DNA
Thomas G. W. Edwardson, Karina M. M. Carneiro, Christopher J. Serpell, Hanadi F. Sleiman
Development and characterization of gene silencing DNA cages
Johans J. Fakhoury, Christopher K. McLaughlin, Thomas W. Edwardson, Justin W. Conway, Hanadi F. Sleiman
Gold nanoparticle 3D-DNA building blocks: high purity preparation and use for modular access to nanoparticle assemblies.
Kai Lin Lau, Graham D. Hamblin, Hanadi F. Sleiman
2013
Castor KJ, Liu Z, Fakhoury J, Hancock MA, Mittermaier A, Moitessier N, Sleiman HF.
Chem. Eur. J., 2013 Dec 23;19(52):17836-45.
Edwardson TG, Carneiro KM, McLaughlin CK, Serpell CJ, Sleiman HF.
Nat. Chem. 2013 Oct;5(10):868-75.
Tefashe UM, Metera KL, Sleiman HF, Mauzeroll J.
Langmuir, 2013 Oct 15; 29(41):12866-73.
Intercalators as molecular chaperones in DNA self-assembly.
Greschner AA, Bujold KE, Sleiman HF.
J. Am. Chem. Soc. 2013 Jul 31;135(30):11283-8.
Long-range assembly of DNA into nanofibers and highly ordered networks.
Carneiro KM, Avakyan N, Sleiman HF.
Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2013 May-Jun;5(3):266-85.
Hamblin GD, Hariri AA, Carneiro KM, Lau KL, Cosa G, Sleiman HF.
ACS Nano. 2013 Apr 23;7(4):3022-8.
2012
Greschner AA, Toader V, Sleiman HF.
J. Am. Chem. Soc. 2012 Sep 5;134(35):14382-9.
Three-dimensional organization of block copolymers on “DNA-minimal” scaffolds.
McLaughlin CK, Hamblin GD, Hänni KD, Conway JW, Nayak MK, Carneiro KM, Bazzi HS, Sleiman HF.
J. Am. Chem. Soc. 2012 Mar 7;134(9):4280-6.
Hamblin GD, Carneiro KM, Fakhoury JF, Bujold KE, Sleiman HF.
J. Am. Chem. Soc. 2012 Feb 15;134(6):2888-91. Erratum in: J Am Chem Soc. 2012 Mar 21;134(11):5426.
Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.
Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF.
ChemMedChem. 2012 Jan 2;7(1):85-94.
2011
McLaughlin CK, Hamblin GD, Sleiman HF.
Chem. Soc. Rev. 2011 Dec;40(12):5647-56. Review.
A facile, modular and high yield method to assemble three-dimensional DNA structures.
McLaughlin CK, Hamblin GD, Aldaye FA, Yang H, Sleiman HF.
Chem. Commun. (Camb). 2011 Aug 21;47(31):8925-7. doi: 10.1039/c1cc11726b. Epub 2011 Jul 11.
Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions.
Yang H, Lo PK, McLaughlin CK, Hamblin GD, Aldaye FA, Sleiman HF.
Methods Mol. Biol. 2011;749:33-47. doi: 10.1007/978-1-61779-142-0_3.
Chiral metal-DNA four-arm junctions and metalated nanotubular structures.
Yang H, Altvater F, de Bruijn AD, McLaughlin CK, Lo PK, Sleiman HF.
Angew. Chem. Int. Ed. Engl. 2011 May 9;50(20):4620-3. doi: 10.1002/anie.201007403. Epub 2011 Apr 26. No abstract available.
2010
Loading and selective release of cargo in DNA nanotubes with longitudinal variation.
Lo PK, Karam P, Aldaye FA, McLaughlin CK, Hamblin GD, Cosa G, Sleiman HF.
Nat. Chem. 2010 Apr;2(4):319-28. doi: 10.1038/nchem.575. Epub 2010 Mar 14.
Self-assembly of three-dimensional DNA nanostructures and potential biological applications.
Lo PK, Metera KL, Sleiman HF.
Curr. Opin. Chem. Biol. 2010 Oct;14(5):597-607. doi: 10.1016/j.cbpa.2010.08.002. Epub 2010 Sep 24. Review.
Wen Y, McLaughlin CK, Lo PK, Yang H, Sleiman HF.
Bioconjug. Chem. 2010 Aug 18;21(8):1413-6. doi: 10.1021/bc100160k.
Templated synthesis of DNA nanotubes with controlled, predetermined lengths.
Lo PK, Altvater F, Sleiman HF.
J. Am. Chem. Soc. 2010 Aug 4;132(30):10212-4. doi: 10.1021/ja1017442.
Carneiro KM, Aldaye FA, Sleiman HF.
J. Am. Chem. Soc. 2010 Jan 20;132(2):679-85. doi: 10.1021/ja907735m.
2009
Templated ligand environments for the selective incorporation of different metals into DNA.
Yang H, Rys AZ, McLaughlin CK, Sleiman HF.
Angew Chem Int Ed Engl. 2009;48(52):9919-23. doi: 10.1002/anie.200904186. No abstract available.
Yang H, McLaughlin CK, Aldaye FA, Hamblin GD, Rys AZ, Rouiller I, Sleiman HF.
Nat Chem. 2009 Aug;1(5):390-6. doi: 10.1038/nchem.290. Epub 2009 Jul 24.
Modular construction of DNA nanotubes of tunable geometry and single- or double-stranded character.
Aldaye FA, Lo PK, Karam P, McLaughlin CK, Cosa G, Sleiman HF.
Nat Nanotechnol. 2009 Jun;4(6):349-52. doi: 10.1038/nnano.2009.72. Epub 2009 Apr 12.
Lo PK, Sleiman HF.
J Am Chem Soc. 2009 Apr 1;131(12):4182-3. doi: 10.1021/ja809613n.
Pierce SE, Kieltyka R, Sleiman HF, Brodbelt JS.
Biopolymers. 2009 Apr;91(4):233-43. doi: 10.1002/bip.21130.
2008
Assembling materials with DNA as the guide.
Aldaye FA, Palmer AL, Sleiman HF.
Science. 2008 Sep 26;321(5897):1795-9. doi: 10.1126/science.1154533. Review.
A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor.
Kieltyka R, Englebienne P, Fakhoury J, Autexier C, Moitessier N, Sleiman HF.
J Am Chem Soc. 2008 Aug 6;130(31):10040-1. doi: 10.1021/ja8014023. Epub 2008 Jul 11.
Templated synthesis of highly stable, electroactive, and dynamic metal-DNA branched junctions.
Yang H, Sleiman HF.
Angew Chem Int Ed Engl. 2008;47(13):2443-6. doi: 10.1002/anie.200703741.
Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders.
Kieltyka R, Fakhoury J, Moitessier N, Sleiman HF.
Chemistry. 2008;14(4):1145-54.
2007
Modular access to structurally switchable 3D discrete DNA assemblies.
Aldaye FA, Sleiman HF.
J Am Chem Soc. 2007 Nov 7;129(44):13376-7. Epub 2007 Oct 16. No abstract available.
Guest-mediated access to a single DNA nanostructure from a library of multiple assemblies.
Aldaye FA, Sleiman HF.
J Am Chem Soc. 2007 Aug 22;129(33):10070-1. Epub 2007 Aug 1.
Slim M, Durisic N, Grutter P, Sleiman HF.
Chembiochem. 2007 May 7;8(7):804-12.
Aldaye FA, Sleiman HF.
J Am Chem Soc. 2007 Apr 11;129(14):4130-1. Epub 2007 Mar 17. No abstract available.
Molecule-responsive block copolymer micelles.
Ishihara Y, Bazzi HS, Toader V, Godin F, Sleiman HF.
Chemistry. 2007;13(16):4560-70.
pre-2007
Sequential self-assembly of a DNA hexagon as a template for the organization of gold nanoparticles.
Aldaye FA, Sleiman HF.
Angew Chem Int Ed Engl. 2006 Mar 27;45(14):2204-9. No abstract available.
Hydrogen-bond self-assembly of DNA-analogues into hexameric rosettes.
Rakotondradany F, Palmer A, Toader V, Chen B, Whitehead MA, Sleiman HF.
Chem Commun (Camb). 2005 Nov 21;(43):5441-3. Epub 2005 Oct 4.
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Mitra D, Di Cesare N, Sleiman HF.
Angew Chem Int Ed Engl. 2004 Nov 5;43(43):5804-8.
Slim M, Sleiman HF.
Bioconjug Chem. 2004 Sep-Oct;15(5):949-53.
Rezvani A, Bazzi HS, Chen B, Rakotondradany F, Sleiman HF.
Inorg Chem. 2004 Aug 9;43(16):5112-9.
Rakotondradany F, Whitehead MA, Lebuis AM, Sleiman HF.
Chemistry. 2003 Oct 6;9(19):4771-80.
Vargas-Baca I, Mitra D, Zulyniak HJ, Banerjee J, Sleiman HF.
Angew Chem Int Ed Engl. 2001 Dec 17;40(24):4629-4632.