Using our skills as chemists, we seek to develop new systems for diagnostics and drug delivery using the programmability and biocompatibility of DNA. We are currently working on projects to understand how DNA nanostructures behave in vivo.
Utilizing only a minimal set of DNA strands, we build unique 3D structures for uses in applications such as drug delivery and organization of other materials. This strategy allows us to make complex constructs using less DNA than other methods.
In the Sleiman lab, we work towards interfacing DNA with many other materials, including organic molecules, metal ions, and inorganic nanomaterials, to explore how DNA can be used to modify and organize these moieties. We also make sequence-defined polymers with DNA.